Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis

ObjectiveTo evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis.MethodsExpression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3.ResultsIn MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells.InterpretationThe lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.