Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065483 | Journal of Neuroimmunology | 2007 | 9 Pages |
Abstract
HLA-E is a ligand for the immune-inhibitory NKG2A receptor expressed on NK and T cells. To investigate HLA-E expression and immune cell infiltration in human astrocytic tumors in vivo, we analyzed normal CNS controls and astrocytomas of all WHO grades by immunohistochemistry. Both, CD8+ immune cell infiltration and HLA-E expression were significantly higher in astrocytic tumors than in normal brain. Further, HLA-E expression levels and immune cell infiltration were significantly correlated in WHO grade IV glioblastomas. Thus, HLA-E overexpression in glioblastomas may be triggered by T and NK cell infiltration.
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Authors
Michel Mittelbronn, Perikles Simon, Christian Löffler, David Capper, Benedikt Bunz, Patrick Harter, Holger Schlaszus, Ariane Schleich, Ghazaleh Tabatabai, Benjamin Goeppert, Richard Meyermann, Michael Weller, Jörg Wischhusen,