Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065493 | Journal of Neuroimmunology | 2007 | 4 Pages |
Abstract
Lymphocyte and monocyte brain infiltration determines inflammation in multiple sclerosis. The trafficking of these cells into the CNS results from the VLA-4 binding with its ligand on brain endothelial cells. MS patients treated with an antibody against the alpha-4 subunit, which inhibits this interaction, prevents brain lesion development. We investigated the association between VLA-4 gene polymorphisms and MS in a study on 275 patients and 255 controls. No differences were detected, thus suggesting that these polymorphisms are not a significant genetic risk factor for susceptibility to MS in Italy.
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Authors
V. Andreoli, R. Cittadella, P. Valentino, F. Condino, A. La Russa, M. Liguori, I. Manna, P. Spadafora, R. Nisticò, D. Pirritano, A. Clodomiro, A. Quattrone,