Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065496 | Journal of Neuroimmunology | 2007 | 10 Pages |
Abstract
Patients with relapsing–remitting (RR) and secondary progressive (SP) forms of multiple sclerosis (MS), although in long-term clinical remission, showed different patterns of increased expressions of the activation markers: CD69, CD40L, and both membrane/surface and cytoplasmic CTLA-4 (mCTLA-4 and cCTLA-4, respectively) in freshly isolated peripheral blood (PB) CD4+ T cells compared with controls. Also observed were dysregulated responses to ex vivo stimulation in both groups of MS patients accompanied by increased IFN-gamma synthesis. Our findings may suggest that the mechanisms leading to each clinical form of the disease may be heterogeneous.
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Authors
A. Kosmaczewska, M. Bilinska, L. Ciszak, L. Noga, E. Pawlak, A. Szteblich, R. Podemski, I. Frydecka,