Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065523 | Journal of Neuroimmunology | 2008 | 6 Pages |
Abstract
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). In MS, myeloid dendritic cells (mDCs) secrete elevated amounts of IL-23, a potent proinflammatory cytokine, compared to healthy donors. Here, we examined the role of CD46, a complement binding factor, in mDCs by analyzing cytokine and chemokine production in healthy donors and patients with MS. There were striking differences between these groups with increased IL-23p19, CCL3 and CCL5 production, but decreased CCL2 levels in patients. This demonstrates major differences of DC activation upon CD46 activation, with a potential role in the pathogenesis of MS.
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Authors
Adi Vaknin-Dembinsky, Gopal Murugaiyan, David A. Hafler, Anne L. Astier, Howard L. Weiner,