Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065541 | Journal of Neuroimmunology | 2007 | 8 Pages |
Abstract
IL-10 is an anti-inflammatory cytokine that suppresses synthesis of proinflammatory cytokines and their receptors. Here we tested the possibility that TNFα-induced hormone resistance in myoblasts might be overcome by IL-10. We found that IL-10 restores myogenesis by suppressing the ability of exogenous TNFα to inhibit IGF-I-induced myogenin. This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair TNFα-induced IL-6 synthesis or ERK1/2 phosphorylation. Instead, IL-10 acts to prevent TNFα-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFα-induced resistance to IGF-I.
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Authors
Klemen Strle, Robert H. McCusker, Lynn Tran, Alexandra King, Rodney W. Johnson, Gregory G. Freund, Robert Dantzer, Keith W. Kelley,