Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065591 | Journal of Neuroimmunology | 2007 | 7 Pages |
Abstract
The human T cell lymphotropic/leukaemia virus type I (HTLV-I) causes HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The multidrug resistance associated protein 1 (ABCC1) plays multiple functions in physiopathologic responses. The expression and activity of ABCC1 was studied in T lymphocytes from uninfected and HTLV-I-infected individuals (both asymptomatic and symptomatic/HAM/TSP). ABCC1 expression and activity was reduced to nearly half in T lymphocytes from infected patients compared to control lymphocytes. Only 51.6% of CD4+ cells from HAM/TSP patients expressed ABCC1 whereas this was seen in 60.3% from asymptomatic individuals, compared to an expression of around 86% in controls. Our results suggest that ABCC1 is negatively regulated in HTVL-I infection, supplying a novel target to investigate the pathogenesis of HTLV-I.
Keywords
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Authors
Juliana Echevarria-Lima, Vivian M. Rumjanek, Fernanda Kyle-Cezar, Ramza C. Harab, Ana Claudia Celestino B. Leite, Débora dos Santos Ornellas, Marcelo Marcos Moralles, Abelardo Q.C. Araújo, Maria José Andrada-Serpa,