Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065656 | Journal of Neuroimmunology | 2008 | 7 Pages |
Abstract
We explored the parameters of central and peripheral tolerance in patients with stable relapsing–remitting multiple sclerosis, treated or not with IFN-β. TREC-positive T cells were lower in patients compared with controls, mainly in CD4+ subset, compatible with a thymus dysfunction or an expansion of peripheral lymphocytes. Compared to controls, the frequency of activated CD4+CD25+ T cells was higher in patients without modification of the CD4+CD25high T cell proportion. The IFN-β-treatment did not modify the TREC-positive cell frequency nor the naive/memory T cell subset percentage but was associated with lower blood lymphocyte count and a lower frequency of CD4+CD45RChigh subset.
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Authors
Bénédicte Puissant-Lubrano, Frédérique Viala, Peter Winterton, Michel Abbal, Michel Clanet, Antoine Blancher,