Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065717 | Journal of Neuroimmunology | 2006 | 14 Pages |
Abstract
Serotonin plays a role in T cell activation, but there is no clear consensus of which of the 14 serotonergic receptors control this activations pathway. We have used a broad range of serotonergic receptor antagonists to define the functional involvement of these receptors governing the proliferation of primary T cells as well as in T cell lines. Our data shows that antagonism of the 5-HT1B receptor inhibits the proliferation of both human and murine primary helper T cells and of human helper T cell lines. As a whole, our data suggest that other serotonergic receptors may contribute to the proliferative signals, but the 5-HT1B receptor plays the most dominant role.
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Authors
Jun Yin, Ross H. Albert, Anna P. Tretiakova, Bradford A. Jameson,