Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065727 | Journal of Neuroimmunology | 2006 | 7 Pages |
Abstract
We detected anti-triosephosphate isomerase antibodies (anti-TPI) in cerebrospinal fluid (CSF) in 5 of 12 neuropsychiatric lupus patients (41.6%) by Western blotting. C3d index was significantly higher in anti-TPI-positive patient (n = 5, median 0.446) than in anti-TPI-negative patient (n = 7, median 0.098) (p = 0.019) CSF samples. TPI was detected from immune complexes (IC) isolated from CSF in 2 of 2 anti-TPI-positive patients tested and was not detected from IC in 5 of 5 anti-TPI-negative patients tested. Our results suggest that anti-TPI form IC in CSF and contribute to the pathogenesis of neuropsychiatric lupus by activating the complement system.
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Authors
Tomomi Sasajima, Hiroshi Watanabe, Shuzo Sato, Yukio Sato, Hiromasa Ohira,