Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065799 | Journal of Neuroimmunology | 2007 | 10 Pages |
Abstract
We have assessed the complexity in T cell recognition of the immunodominant 35–55 region of myelin oligodendrocyte glycoprotein (MOG) in C57BL/6 mice. Immunization with the p35–55 peptide generated two types of T cell, recognizing either a cryptic, or a naturally-processed epitope. Clear differences in the recognition of residues within a core sequence of 40-48 were observed. The majority of the p35–55-reactive repertoire in vivo appeared responsive to the intact autoantigen, supporting the notion of a failure of central tolerance to this region of MOG. Our data also provide a basis for exploring the requirements for antigen processing of MOG.
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Authors
Claire H. Sweenie, Karen J. Mackenzie, Alero Rone-Orugboh, Michael Liu, Stephen M. Anderton,