Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065802 | Journal of Neuroimmunology | 2007 | 10 Pages |
Abstract
Uptake of antigens and bacteria over the follicle-associated epithelium (FAE) is increased after chronic psychological stress. We investigated whether stress affects the immune response to particle-conjugated antigens taken up via the FAE. Rats were submitted to two 10-day periods of water avoidance stress and orally immunized during these periods. Stressed immunized rats displayed altered cell populations and a Th1-skewed immune response within the lymphoid follicles, together with enhanced delayed-type hypersensitivity. We conclude that chronic stress affects the cell-mediated immune response after oral immunization, which may have implications for the understanding of allergic and autoimmune diseases and development of oral vaccines.
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Authors
Åsa V. Keita, Linda Stertman, Yi-Qian Sun, Agneta Larhed, Ingvar Sjöholm, Johan D. Söderholm,