Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065815 | Journal of Neuroimmunology | 2007 | 5 Pages |
Abstract
Administration of high-dose myelin antigen induces massive T cell apoptosis in experimental autoimmune encephalomyelitis (EAE) but the nature of the target cells remains elusive. Here we have used a cell line established in eGFP-transgenic Lewis rats to distinguish between pathogenic and bystander T cells in adoptive transfer EAE. Intravenous application of gpMBP strongly reduced the amount of encephalitogenic cells in spinal cord and spleen while the number of the other T cells remained constant. This could be attributed to their differential sensitivity to apoptosis. Thus, antigen therapy selectively targets pathogenic T cells and should therefore limit potential adverse effects.
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Authors
Denise Tischner, Andreas Weishaupt, Jens van den Brandt, Chi Wang Ip, Thomas Kerkau, Ralf Gold, Holger M. Reichardt,