| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3065825 | Journal of Neuroimmunology | 2007 | 7 Pages |
Abstract
To determine the gene expression of IFNAR1, IFNAR2 and MxA protein and the association with IFNβ treatment response in MS patients.MS patients treated with IFNβ had a significant decrease in IFNAR1 and IFNAR2 expression, and a significant increase in MxA compared to non-treated patients and healthy controls. Also, those patients who had a good response to treatment had a significant decrease in IFNAR1 and IFNAR2 expression compared to non-responders, non-treated patients and healthy controls.IFNβ influences the expression of its receptors, and is greater in patients who respond to IFNβ treatment. This down-regulation could be indicative of the response to IFNβ.
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Authors
Begoña Oliver, Cristobalina Mayorga, Victoria Fernández, Laura Leyva, Antonio León, Gloria Luque, Juan C. López, Jose A. Tamayo, Maria J. Pinto-Medel, Enrique de Ramon, Eva Blanco, Ana Alonso, Oscar Fernández,