Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065855 | Journal of Neuroimmunology | 2007 | 18 Pages |
Abstract
Rhesus monkeys immunized with MOG34-56, a dominant T-cell epitope from myelin/oligodendrocyte glycoprotein, develop an acute neurological disease resembling acute disseminated encephalomyelitis (ADEM) in humans. The typical large demyelinated lesions and mononuclear infiltrates in the monkey brains are caused by MOG34-56 T-cells. We show that MOG34-56-reactive CD4+ and CD8+ T-cells are induced in monkeys immunized with a peptide from the human CMV major capsid protein (UL86; 981-1003), that shares sequence similarity with MOG34-56. Monkeys sensitized against the viral peptide and subsequently challenged with MOG34-56 display histological signs of encephalitis, but do not show overt neurological signs.
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Immunology
Authors
Herbert P.M. Brok, Leonie Boven, Marjan van Meurs, Nicole Kerlero de Rosbo, Liesbeth Celebi-Paul, Yolanda S. Kap, Anwar Jagessar, Rogier Q. Hintzen, Geoff Keir, Jeffrey Bajramovic, Avraham Ben-Nun, Jan Bauer, Jon D. Laman, Sandra Amor, Bert A. 't Hart,