Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065919 | Journal of Neuroimmunology | 2006 | 6 Pages |
Abstract
We investigate the cytokine profile in the cerebrospinal fluid (CSF) and serum of patients with spinal cord schistosomiasis (SCS). Increased levels of IL-1β, IL-4, IL-6 and IL-10 and low concentrations of TNF-α and IFN-γ were observed in both CSF and serum. CSF showed higher levels of IL-4 and IL-6 when compared to the paired serum samples. A negative correlation between the concentrations of IL-10 and IFN-γ was observed in the CSF. These findings suggest an inflammatory as well as a skewed type-2 immune response that probably occur both locally and systemically and may be involved in the pathogenesis of SCS.
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Authors
Teresa Cristina Abreu Ferrari, Paulo Roberto Rocha Moreira, Márcio José Sampaio, Aloísio Sales da Cunha, José Teotônio de Oliveira, Giovanni Gazzinelli, Rodrigo Correa-Oliveira,