Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3065926 | Journal of Neuroimmunology | 2006 | 8 Pages |
Abstract
Beneficial effects of intravenous immunoglobulin (IVIg) in relapsing-remitting multiple sclerosis (MS) have been described, including a decrease of brain atrophy. We have previously shown that activated T cells kill neurons in culture. In this manuscript, we show that the pretreatment of activated T cells with IVIg attenuates T cell neurotoxicity. This is attributed to the ability of IVIg to decrease the adhesion of T cells onto neurons, possibly through an effect on LFA-1, and by lowering the levels of Fas and FasL on T cells. Our results are relevant to understanding how therapies affect the MS disease process.
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Authors
Angela D. Janke, Fabrizio Giuliani, V. Wee Yong,