| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3065951 | Journal of Neuroimmunology | 2006 | 9 Pages |
Abstract
We report a case of myasthenia gravis associated with marked expansion of an unusual CD16+CD56−2B4+ NK subset. These atypical cells were characterized by poor cytotoxicity against CD48+ target cells and high proliferation due to 2B4/CD48 interaction. IL18, IFN-γ and TGF-β levels were profoundly different in this patient than in healthy donors. Immunosuppressive treatment induced disease remission and decreased the CD16+CD56−2B4+NK cells count. Our data suggest that expansion of this NK subset in myasthenia gravis patients may account for the deleterious NK cell functioning that occurs in this autoimmune disease.
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Authors
Stéphanie Nguyen, Véronique Morel, Magali Le Garff-Tavernier, Francis Bolgert, Véronique Leblond, Patrice Debré, Vincent Vieillard,