Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3066014 | Journal of Neuroimmunology | 2006 | 11 Pages |
Abstract
Immune complexes and classical complement pathway play vital roles in experimental autoimmune myasthenia gravis (EAMG). To analyze the role of immune complex receptors in EAMG, FcγRIII knockout (KO) mice were immunized with AChR and were found out to be resistant to EAMG induction. This was associated with reduced neuromuscular junction deposits, lymph node cell (LNC) IL-6 production and serum complement levels. EAMG resistance of anti-C1q Ab-administered mice was also associated with reduced LNC IL-6 production and neuromuscular junction deposits, indicating C1q involvement in EAMG resistance. The data provide the first direct genetic evidence for Fcγ receptor involvement in EAMG pathogenesis.
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Authors
Erdem Tüzün, Shamsher S. Saini, Huan Yang, Dhivyaa Alagappan, Stephen Higgs, Premkumar Christadoss,