Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3066045 | Journal of Neuroimmunology | 2006 | 9 Pages |
Glucocorticoids remain the treatment of choice for MS relapses. However, little is known on the effect of intravenous methylprednisolone (IVMP) on dendritic cells (DCs) and regulatory T-cells (TReg). Our main goal was to quantify circulating myeloid and plasmacytoid DCs (mDCs and pDCs), and TReg at MS relapse versus healthy controls; and to analyse the short-term changes after IVMP for MS relapse. MS patients at relapse compared to controls showed higher %CD4+CD25high+ TReg (p < 0.01). After 5-days of IVMP, activated T-lymphocytes (p = 0.001), pDCs (p < 0.0001), and CD11c+ mDCs (p < 0.0001) decreased. By contrast, CD4+CD25+ and CD4+CD25high+ TReg further increased (p < 0.0001 both). Changes on these subsets may play a relevant role in the immunosuppressive activity of this drug.