Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3066071 | Journal of Neuroimmunology | 2006 | 9 Pages |
Abstract
A devastating consequence of HSV-1 infection is development of HSV-1-induced encephalitis (HSVE). While only a minority of individuals infected with HSV-1 experiences HSVE, clearly defined variables that consistently predict development of the disease remain to be elucidated. The current study examined the effects of a single dose of morphine prior to infection with HSV-1 on the development of HSVE in BALB/cByJ mice. Acute morphine exposure was observed to potentiate the development of HSVE in HSV-1 infected mice. The present data implicate a potential role for the blood-brain barrier in the development of HSVE in morphine-treated mice.
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Authors
Daniel T. Lioy, Patricia A. Sheridan, Sean D. Hurley, James R. Walton, Amy M. Martin, John A. Olschowka, Jan A. Moynihan,