Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3066079 | Journal of Neuroimmunology | 2006 | 10 Pages |
Abstract
Infections can trigger or exacerbate the course of Multiple Sclerosis, and both bacterial and viral agents have been implicated. These agents are recognized by host cells via pathogen-associated molecular patterns activating TLRs. We investigated the role that PAMPs play in the animal model Experimental Autoimmune Encephalomyelitis, and found various MyD88-dependent PAMPs can participate as the adjuvant to induce EAE. Studies with IRAK1-deficient mice suggest that signaling through TLRs is not required in the target organ to develop disease. This suggests that PAMPs play an important role in priming of autoreactive T cells in EAE and potentially MS.
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Authors
Baranda S. Hansen, Rehana Z. Hussain, Amy E. Lovett-Racke, James A. Thomas, Michael K. Racke,