Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3066113 | Journal of Neuroimmunology | 2006 | 11 Pages |
Myasthenia gravis (MG) is mostly caused by anti-acetylcholine receptor (AChR) auto-antibodies (Abs). Such Abs are undetectable in 10–15% of MG patients, but many have anti-muscle-specific kinase (MuSK) Abs. We injected recombinant rat-MuSK extracellular domain in H-2a, H-2b, H-2bm12 and H-2d mice. Certain strains exhibited exercise-induced fatigue, tremors, weight loss, and some died after 2–3 injections. Compound muscle action potentials showed decrement with low-frequency repetitive nerve stimulation. Miniature endplate potentials decreased, suggesting lower numbers of endplates functional AChRs. Myasthenic sera inhibited agrin-induced AChR aggregation in C2C12 myotubes. Conclusion: Anti-MuSK Abs induce MG, which might also result from blocking the agrin-signaling pathway.