Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3066116 | Journal of Neuroimmunology | 2006 | 10 Pages |
Abstract
A novel triptolide derivative (5R)-5-hydroxytriptolide (LLDT-8) has been shown to have potent immunosuppressive activities. Here LLDT-8 was evaluated in experimental autoimmune encephalomyelitis (EAE), the model of multiple sclerosis (MS). LLDT-8 reduced the incidence and severity of EAE, which was associated with the inhibition of the MOG 35–55 lymphocyte recall response, anti-MOG 35–55 T cell responses, interleukin (IL)-2 and interferon (IFN)-γ production. In vitro, LLDT-8 inhibited primary T cells proliferation, division, IL-2 and IFN-γ production stimulated with anti-CD3/28. These findings highlight the fact that LLDT-8 prevents EAE by suppressing T cell proliferation and activation, with a potential for treatment of MS.
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Authors
Yun-Feng Fu, Yi-Na Zhu, Jia Ni, Xiang-Gen Zhong, Wei Tang, Ru Zhou, Yu Zhou, Jia-Rong Dong, Pei-Lan He, Hua Wan, Yuan-Chao Li, Yi-Fu Yang, Jian-Ping Zuo,