Mandibular metastasis as the first manifestation of prostate adenocarcinoma

Metastatic lesions to the oral region are uncommon and account for 1% of all malignancies of the jaw. Reported is a rare case of mandibular metastasis without other osseous metastases as the first manifestation of prostate adenocarcinoma. A 60-year-old man was referred due to a complaint of swelling in the left mandible with no other symptoms. A diagnosis of metastatic prostate adenocarcinoma of the mandible was made through biopsy specimens from the mandible by immunohistochemistry for prostate-specific antigen (PSA) and from urological examination. After starting hormonal therapy, elevated serum levels of PSA markedly decreased. The therapy was extremely effective not only in the primary lesion but also in the metastatic mandibular lesion.