Histological evaluation of cell behavior in soft tissue around a 4-META/MMA-TBB resin cement applied to the bone tissue in rats

ObjectivesThe aim of this study was to evaluate the behavior of the soft tissue in rats around a 4-META/MMA-TBB resin and other types of bone cement.Methods4-META/MMA-TBB resin (SBV) and PMMA bone cement (SIMP) were applied to wounds made in the left femurs of 24 male Sprague-Dawley rats. Rats were sacrificed at 3 or 7 days after the operation; then, histological evaluation and immunohistochemical evaluation using a CD68 antibody were performed.ResultsHistologically, at 3 days after the operation, inflammation against operative stress was observed in all groups. At 7 days, marked formation of granulation tissue was recognized in the SIMP group compared with the SBV and control groups. Immunohistochemically, at 7 days, a number of CD68-positive cells were recognized in the SIMP group compared with the SBV and control groups.ConclusionThese results suggest that SBV has a superior biocompatibility to SIMP in the soft tissue around the rat femur.