Intraosseous lymphoma of the oral and maxillofacial regions: Report of our experiences, involving some difficult cases to be diagnosed

Intraosseous lymphoma in the maxilla or mandible is sometimes difficult to diagnose because of the absence of specific signs and symptoms. This study reports five cases of intraosseous lymphoma in the oral and maxillofacial regions. There were four cases of diffuse large B-cell lymphoma (DLBCL), including EBV-positive DLBCL of the elderly, and one of Burkitt's lymphoma. Regarding the tumor sites, three of the cases were in the maxilla, while two were in the mandible. Two of the conditions were clinically diagnosed as inflammatory diseases at the time of their first examination. Two patients died of their lymphoma during the follow-up period. Based on these events and findings, we clearly realized that careful examination is necessary to be diagnosed early, which results in a much better prognosis. Moreover, maxillofacial surgeons need to keep following up carefully on their patients to immediately recognize any recurrences after completion of treatment.