| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3160392 | Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology | 2015 | 5 Pages |
Abstract
Methotrexate (MTX) is widely used to treat rheumatoid arthritis (RA), but methotrexate-associated lymphoproliferative disorder (MTX-LPD) has recently been occasionally reported. We encountered an MTX-LPD patient with the complication of osteonecrosis of the maxilla perforating the maxillary sinus. The patient was a 76-year-old female being treated with MTX and anti-TNFα antibody for RA. Chemotherapy was performed for the initial development of MTX-LPD in the upper gingiva after the withdrawal of MTX and anti-TNFα antibody. MTX-LPD remitted, but osteonecrosis reaching the maxillary sinus and its perforation developed, for which sequestrectomy was performed. The postoperative course was favorable without recurrence for 30 months.
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Authors
Shota Saito, Takuya Murakami, Shinya Koshinuma, Tomoki Higo, Yasuhiko Tsutsumi, Gaku Yamamoto,