| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3196491 | Dermatologica Sinica | 2015 | 5 Pages |
Background/ObjectivesRecently, fibrotic diseases such as hypertrophic scar, keloid, and scleroderma have been treated with UV-A1 radiation with encouraging results. However, conventional UV light sources are bulky and expensive. In this study, we aimed to verify the effectiveness of a portable UV-A1 radiation device in treating hypertrophic scars.Materials and methodsA light-emitting diode array that emitted 365 ± 5 nm (UV-A1) was used to irradiate fibroblasts and hypertrophic scar in a rabbit model.ResultsIn cell cultures, UV-A1 light exposure inhibited post-wound cell migration and reduced the total amount of soluble collagen production in fibroblasts. Type I collagenase production and its activity increased after treatment. On the rabbit ear, UV-A1 light irradiation reduced the thickness of hypertrophic scars, confirming the antifibrotic effect in vivo.ConclusionThese results support the potential of a portable UV-A1 light device in treating hypertrophic scar.
