Nanoparticles in biomolecular detection

The use of nanoparticles as labels in biomolecular detection in place of conventional molecular fluorophores has led to improvements in sensitivity, selectivity, and multiplexing capacity. Nevertheless, further simplification is needed to take these technologies from the laboratory to point of care. Here, we summarize the latest developments in the use of nanoparticles as labels, especially in bioaffinity sensors for the detection of nucleic acids and proteins.