Article ID Journal Published Year Pages File Type
32738 Nano Today 2009 16 Pages PDF
Abstract

Nanostructures self-assembled from amphiphilic functional copolymers have emerged as safe and efficient nanocarriers for delivery of anticancer therapeutics. The development of this class of nanostructures has advanced from basic spherical micelles for delivery of small molecular hydrophobic drugs to a more complex functional structure for more efficient delivery of a wide range of therapeutics including small molecular drugs, macromolecular proteins and genes. This review describes physiological barriers for delivery of therapeutics, summarizes various approaches to overcome these barriers, and discusses the challenges in the current approaches for cancer therapy and perspectives for future solutions.

Related Topics
Physical Sciences and Engineering Chemical Engineering Bioengineering
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