Colitis microscópica y exposición a fármacos: una revisión crítica

At present we have no universally accepted criteria for establishing cause-effect relationships in adverse drug reactions, although several methods have provide us with different levels of likelihood. Thus, the existence of a high probability of MC occurrence as an adverse effect to a specific drug has been shown only in individual cases by using chronological (exposure, effect of withdrawal and relapse with re-exposure) and semiological criteria. Although case-control studies have repeatedly shown significant associations between drug exposure and MC, variability in their designs, including reference populations used and the criteria considered in defining drug exposure, requires a detailed analysis. This article critically examines the complex relationship between drugs, diarrhea and MC, to conclude that a likely cause-effect relationship has only been described for few drugs and in individual cases of MC.