Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3289204 | Gastroenterología y Hepatología | 2007 | 5 Pages |
Abstract
Firstly, d-ADC shows a fairly exclusive genetic-molecular profile, found in 70% of cases; this profile consists of the association of the K-ras oncogene and inactivation of the tumor suppressor genes p16, p53 and DPC4. Secondly, a series of lesions in the ductal epithelium, in healthy pancreatic tissue close to a d-ADC, have been identified, which seem to represent precancerous histopathological stages. Lastly, there is the suspicion that the mutations defining this geneticmolecular profile appear gradually, in a certain sequence, throughout the stages of progression. Most probably, rather than the order of appearance, the accumulation of these genetic-molecular events are what prompt quiescent ductal epithelium to progress to mitogenic cellular hyperplasia, leading to irreversible mutagenic cellular dysplasia.
Related Topics
Health Sciences
Medicine and Dentistry
Gastroenterology
Authors
Paloma Sánchez-Fayos Calabuig, MarÃa Jesús MartÃn Relloso, Juan Carlos Porres Cubero,