Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3301461 | Gastroenterology Clinics of North America | 2009 | 9 Pages |
Abstract
A vast majority of ulcers of the stomach and duodenum are due to H pylori infection or nonsteroidal anti-inflammatory drug (NSAID) usage. In patients with apparent H pylori negative NSAID negative ulcers, it is essential to ensure that the H pylori tests are not falsely negative and that the patient is not taking mucosal damaging drugs unknowingly. There are a variety of rare causes of true H pylori negative NSAID negative ulcers which need to be considered, including underlying cancer/lymphoma, Crohn's disease, rare infections and the Zollinger Ellison syndrome. Patients with idiopathic ulcers should be maintained on proton pump inhibitor therapy and may require higher doses than traditionally used in H pylori positive ulcers.
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Authors
Kenneth E.L. MD, FMedSci, FRSE,