Article ID Journal Published Year Pages File Type
3370874 Journal of Clinical Virology 2007 4 Pages PDF
Abstract

Surface antigen mutations of hepatitis B virus (HBV) may lead to immune escape and cause failure of immunization. In this report, the development of a chronic HBV infection in a vaccinated renal transplant recipient with pre-existing anti-HBs antibody is documented. The sequencing data showed that the HBV strain carried five amino acid substitutions in the major hydrophilic region of the S protein, one (sS143L) located at the “a” determinant. A commercial HBsAg assay failed to detect the mutant antigen.

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Life Sciences Immunology and Microbiology Applied Microbiology and Biotechnology
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