Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3370874 | Journal of Clinical Virology | 2007 | 4 Pages |
Abstract
Surface antigen mutations of hepatitis B virus (HBV) may lead to immune escape and cause failure of immunization. In this report, the development of a chronic HBV infection in a vaccinated renal transplant recipient with pre-existing anti-HBs antibody is documented. The sequencing data showed that the HBV strain carried five amino acid substitutions in the major hydrophilic region of the S protein, one (sS143L) located at the “a” determinant. A commercial HBsAg assay failed to detect the mutant antigen.
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Authors
A. Arzu Sayiner, Harun Agca, Aylin Sengonul, Ali Celik, Mesut Akarsu,