Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
338772 | Schizophrenia Research | 2008 | 8 Pages |
Abstract
ObjectiveTo examine the efficacy of aripiprazole across symptoms in patients with acute exacerbation of schizophrenia or schizoaffective disorder.MethodsData were pooled from five, 4–6-week acute studies. PANSS Total, Positive, Negative, and General Psychopathology Subscale improvements were analyzed, as well as all 30 individual PANSS items.ResultsAripiprazole had statistically significant decreases versus placebo on PANSS subscales at Week 4, similar to those seen with haloperidol. Aripiprazole-treated patients also showed significant decreases versus placebo in 26 of the 30 PANSS items (all p < 0.05).ConclusionAripiprazole demonstrates statistically and clinically significant efficacy across a range of symptoms in schizophrenia.
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
John M. Kane, Sheila Assunção-Talbott, James M. Eudicone, Andrei Pikalov, Richard Whitehead, David T. Crandall,