Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
339739 | Schizophrenia Research | 2006 | 5 Pages |
Abstract
It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant association with schizophrenia was observed to one SNP marker, rs9658635 (p = 0.0269), and with a 2 marker haplotype (p = 0.0016). Significant association of rs9658635 was then replicated in a second independent cohort (377 schizophrenia and 338 control samples) (p = 0.007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population.
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Authors
Nagahide Takahashi, Ryoko Ishihara, Shinichi Saito, Nobuhisa Maemo, Nagisa Aoyama, Xiofei Ji, Hideki Miura, Masashi Ikeda, Nakao Iwata, Tatsuyo Suzuki, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Norio Ozaki, Toshiya Inada,