Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3397884 | Clinical Microbiology and Infection | 2010 | 6 Pages |
Abstract
The dupA gene of Helicobacter pylori was suggested to be a risk factor for duodenal ulcer but protective against gastric cancer. The present study aimed to re-examine the role of dupA in H. pylori-infected Japanese patients. We found that dupA status was not associated with any gastroduodenal disease, histological score of chronic gastritis or with the extent of interleukin-8 production from gastric cell lines. These results indicate that dupA is unlikely to be a virulence factor of H. pylori in the Japanese population.
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Authors
L.T. Nguyen, T. Uchida, Y. Tsukamoto, A. Kuroda, T. Okimoto, M. Kodama, K. Murakami, T. Fujioka, M. Moriyama,