Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3398117 | Clinical Microbiology and Infection | 2007 | 4 Pages |
Abstract
ABSTRACTThe plasma concentrations of granzymes are considered to reflect the involvement of cytotoxic T-cells and natural killer cells in various disease states. Interferon (IFN)-γ-inducible protein-10 (IP-10) and monokine induced by IFN-γ (Mig) are members of the non-ELR CXC chemokine family that act on T-cells and natural killer cells. This study revealed that the plasma concentrations of granzyme B (but not granzyme A), IP-10 and Mig were higher in 44 Thai patients with definite or possible leptospirosis than in healthy blood donors. These data suggest that activation of cell-mediated immunity is part of the early host response to leptospirosis.
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Authors
M. De Fost, W. Chierakul, R. Limpaiboon, A. Dondorp, N.J. White, T. Van Der Poll,