Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
339899 | Schizophrenia Research | 2009 | 6 Pages |
Abstract
Schizophrenia (SCZ) is a severe neuropsychiatric disorder with a strong genetic basis. We analyzed eight GABRG2 and one DRD5 tag single-nucleotide polymorphisms for association with SCZ in 109 small nuclear families and 229 independent SCZ case-control pairs. The marker rs183294 in the 5′ region of GABRG2 was found to be associated with SCZ in both samples with the C allele over-represented in SCZ cases and over-transmitted in SCZ families (combined z = 9.18; p < 1 × 10− 3). Taken together, the results of the present study suggest that GABRG2 may be involved in SCZ susceptibility, but further studies are required.
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Clement C. Zai, Arun K. Tiwari, Nicole King, Vincenzo De Luca, Daniel J. Mueller, Sajid Shaikh, Greg W.H. Wong, Herbert Y. Meltzer, Jeffrey A. Lieberman, James L. Kennedy,