Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3399129 | Current Opinion in Microbiology | 2013 | 7 Pages |
The aggregation of proteins into amyloid fibers is a common characteristic of many neurodegenerative disorders including Alzheimer's, Parkinson's, and prion diseases. Amyloid formation was originally characterized in these systems and is traditionally viewed as a consequence of protein misfolding and aggregation. An emerging field of study brings functional amyloids, like those produced by bacteria, into the scientific mainstream, and demonstrates a ubiquitous role for amyloids in living systems. This review aims to summarize what is known about the bacterial amyloids and their interactions within various host environments.
► Numerous examples of functional amyloids are emerging in diverse bacterial species. ► Bacterial functional amyloids facilitate a multitude of interactions with the host. ► Functions of bacterial amyloids include roles in: biofilm development, toxin storage, sporulation, and modulation of the immune response.