| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3399204 | Current Opinion in Microbiology | 2011 | 6 Pages |
The emergence of pathogenic bacteria resistant to multiple antimicrobial agents is turning into a major crisis in human and veterinary medicine. This necessitates a serious re-evaluation of our approaches toward antibacterial drug discovery and use. Concurrent advances in genomics including whole-genome sequencing, genotyping, and gene expression profiling have the potential to transform our basic understanding of antimicrobial pathways and lead to the discovery of novel targets and therapeutics.
► Genomics has a multi-dimensional impact on various aspects of the antibiotic development field. ► Dissecting the pathogenesis phenomenon with potential applications in personalized treatment. ► Optimizing antibiotic biosynthesis process. ► Identification of essential genes and virulence factors as novel targets for therapeutics. ► Understanding antibiotics modes of action and emergence of antibiotic resistance.
