Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3399285 | Current Opinion in Microbiology | 2009 | 7 Pages |
Abstract
In all domains of life nucleotide-based second messengers transduce signals originating from changes in the environment or in intracellular conditions into appropriate cellular responses. In prokaryotes cyclic di-GMP has emerged as an important and ubiquitous second messenger regulating bacterial life-style transitions relevant for biofilm formation, virulence, and many other bacterial functions. This review describes similarities and differences in the architecture of the cAMP, (p)ppGpp, and c-di-GMP signaling systems and their underlying signaling principles. Moreover, recent advances in c-di-GMP-mediated signaling will be presented and the integration of c-di-GMP signaling with other nucleotide-based signaling systems will be discussed.
Related Topics
Life Sciences
Immunology and Microbiology
Microbiology
Authors
Christina Pesavento, Regine Hengge,