Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3399485 | Current Opinion in Microbiology | 2007 | 7 Pages |
Abstract
Infectious diseases are a leading cause of mortality worldwide. A major challenge in achieving their eradication is a better understanding of bacterial pathogenesis processes. The recent discovery of small noncoding RNAs (sRNAs) as modulators of gene expression in response to environmental cues has brought a new insight into bacterial regulation. sRNAs coordinate complex networks of stress adaptation and virulence gene expression. sRNAs generally ensure such a regulation by pairing to mRNAs of effector and/or regulatory genes, or by binding to proteins. An updated view on bacterial models responsible for important infections illustrates the key role of sRNAs in the control of pathogenesis
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Authors
Alejandro Toledo-Arana, Francis Repoila, Pascale Cossart,