Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3399616 | Current Opinion in Microbiology | 2008 | 6 Pages |
Abstract
Individually, tumor necrosis factor (TNF) and the various interferons frequently display strong antiviral activities. Certain combinations of these cytokines, however, induce a synergistic antiviral state which is distinct from that induced by either one alone. This novel synergistic antiviral state likely occurs through several possible mechanisms, involves multiple signaling pathways, and inhibits a wider range of viruses than the individual cytokines alone. While underappreciated when first discovered, this synergistic phenomenon is proving to be of a much broader scope than initially thought. More work is needed to refine our understanding of this observation and its physiological implications for anti-pathogen responses.
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Authors
Eric Bartee, Mohamed R Mohamed, Grant McFadden,