Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3416412 | Microbial Pathogenesis | 2016 | 5 Pages |
Abstract
Listeria monocytogenes (Lm), a facultative anaerobic gram-positive bacterium, causes listeriosis. Immune cell apoptosis is considered to be one pathogenic factor for listeriosis. As a deubiquitinase, CYLD is an important regulator both in innate immune response and apoptosis by negatively modulating NF-κB pathway. However the role of CYLD in Lm induced apoptosis remains unclear. Here we found that CYLD is significantly up-regulated in macrophages upon its infection. There is a moderate decrease in Lm proliferation and apoptotic cells in siRNA-induced CYLD knockdown THP-1 cells. Thereby CYLD may be involved in cell apoptosis mediated by Lm infection and its proliferation.
Keywords
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Microbiology
Authors
Changzhi Xu, Ling Yang, Yuan Yuan, Fei Du, Shumin Wang, Xiangfang Wang, Lin Zhu, Buchang Zhang, David Weaver,