Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3416966 | Microbial Pathogenesis | 2010 | 6 Pages |
Abstract
In this study, we identified the Th epitopes in MrkD of Klebsiella pneumoniae, an excellent vaccine candidate antigen. By using the RANKPEP prediction algorithm, we have identified and characterized three Th epitopes within the MrkD antigen, which can be recognized by CD4+ T cells from BALB/c (H-2d) mice. They were M221-235, M175-189, and M264-278. These epitopes have important value for studying the immune response of K. pneumoniae infection and for designing effective vaccine against K. pneumoniae.
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Authors
Yang Li, Zhi-jie Li, Wen-yu Han, Lian-cheng Lei, Chang-jiang Sun, Xin Feng, Chong-tao Du, Tao-feng Du, Jing-min Gu,