| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3422298 | Trends in Microbiology | 2012 | 7 Pages |
Abstract
The development of efficient microbicides, the topically applied compounds that protect uninfected individuals from acquiring HIV-1, is a promising strategy to contain HIV-1 epidemics. Such microbicides should of course possess anti-HIV-1 activity, but they should also act against other genital pathogens, which facilitate HIV-1 transmission. The new trend in microbicide strategy is to use drugs currently used in HIV-1 therapy. The success of this strategy is mixed so far and is impaired by our limited knowledge of the basic mechanisms of HIV-1 transmission as well as by the inadequacy of the systems in which microbicides are tested in preclinical studies.
Related Topics
Life Sciences
Immunology and Microbiology
Microbiology
Authors
Christophe Vanpouille, Anush Arakelyan, Leonid Margolis,