| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3422674 | Trends in Microbiology | 2006 | 4 Pages |
Abstract
To deliver their genetic material into host cells, enveloped viruses have surface glycoproteins that actively cause the fusion of the viral and cellular membranes. Recently determined X-ray crystal structures of the paramyxovirus fusion (F) protein in its pre-fusion and post-fusion conformations reveal the dramatic structural transformation that this protein undergoes while causing membrane fusion. Conformational changes in key regions of the F protein suggest the mechanism by which the F protein is activated and refolds.
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Authors
Charles J. Russell, Laura E. Luque,