Article ID Journal Published Year Pages File Type
3422700 Trends in Microbiology 2008 6 Pages PDF
Abstract

Deletion of genes in a pathogen is commonly associated with a reduction in its ability to cause disease. However, some rare cases have been described in the literature whereby deletion of a gene results in an increase in virulence. Recently, there have been several reports of hypervirulence resulting from gene deletion in Mycobacterium tuberculosis. Here, we explore this phenomenon in the context of the interaction between the pathogen and the host response.

Related Topics
Life Sciences Immunology and Microbiology Microbiology
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